Hepatitis C : An Update

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چکیده

The identifi.cation of the Hepatitis C virus using molecular cloning techniques, besides making the term Non-A Non-B Hepatitis obsolete, enables the development of specif.ic assays for the detection of antibodies in HCV -infected individuals, thus making it possible to obtain sero-epidemiological data of the disease. The carriage of Hepatitis C antibody varies worldwide. The disease is most prevalent in intravenous drug abusers or haemophiliacs. Parenteral transmission is the most important route of transmission. Sexual, intra-familial and perinatal transmissions are uncommon. About 40% could be community-acquired (sporadic). Diagnostic tests include enzyme-linked immunosorbant (ELISA) anti-HCVassay,recombinantimmunoblotassay,HCV-RNAbypolymerase chain reaction and HCVAg. More than 50% of acute cases becomes chronic and runs a benign and indolent course. About 20% progress to cirrhosis and some of these develop hepatocellular carcinoma. Several published trials have consi.stently shown that treatment with interferon i.n some patients is usefuL There is however a relapse rate of 50%. Further trials with interferon and other anti -viral agents like ribavirin are awaited for more effecti.ve treatment.

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تاریخ انتشار 2012